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    Case of the Day
    Thalassemia intermedia

    Modality: X-Ray Modality: X-Ray Modality: X-Ray

    View here all images of this case in different sizes !

    Go to the top of the page ID: 20020126181655
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     Thalassemia intermedia   
     Available images: There are X-Ray images available for this case. [ X-Ray ]   

    M. Paetzel (Cleveland/USA)  

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    9 Years  




    9 year old girl, paleness, hepatosplenomegaly  

     Pathomorphology or Pathophysiology of this disease :

    Autosomal hereditary hemoglobin defect with a resulting hypocromatic, microcytic anemia. Through hemolysis is an iron overload common. Extensive medullary and extramedullary bleeding.  

     Radiological findings:

    X-Ray 1 <- view X-Ray 1

    X-Ray 1: Lateral View

    X-Ray 2 <- view X-Ray 2

    X-Ray 2: Cranium (extensive): Macrocephaly with widend diploe, thinned tabula externa and subperiostal spiculae. Holes in the tablua externa re possible.

    X-Ray 3 <- view X-Ray 3

    X-Ray 3: Hand: Trabelces are affected in the metacarpals. Widening of the bone marrow and thinning of the cortical zone through the hypertophied blood-producing marrow..

    Further typical changes of the increased erythropoeisis is seen in the ribs, facial skeleton and in the vertebral bodies are possible not shown.

    In the MRI (T2): Signal reduction in bone marrow, in the liver and in the spleen (iron deposition).


     Diagnosis confirmation:


     Which DD would be also possible with the radiological findings:

    Other hemolytic anemias (spherocytosis, enzyme defects)  

     Course / Prognosis / Frequency / Other :


     Comments of the author about the case:


     First description / History:






     Most likely etiology:


     Available images: There are X-Ray images available for this case. [ X-Ray ]   
    More cases from these authors: Search M. Paetzel in Medline M. Paetzel (10)     

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