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    Go to the top of the page   ID: 20090427151244 Original case in german  More links about this topic on Pubmed (PubMed Reader)
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    Agenesis Of The Corpus Callosum
    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.

     Pediatric Radiology CasesImages to this case: There are MRI-images available for this case. [ MRI ] View all modalities [ All ]   
     Pediatric Radiology CasesAuthor/s:

    Sanjeeb Kumar Sarma (Down Town Hospital/Guwahati/India), GS Ahmed (Down Town Hospital/Guwahati/India)  

     Pediatric Radiology CasesEmail Address:

    Viewable for logged on visitors (Log on)  

     Pediatric Radiology CasesAge:

    1 Years  

     Pediatric Radiology CasesGender:


     Pediatric Radiology CasesRegion-Organ:

    Head-Brain and brain nerves  

     Pediatric Radiology CasesMost likely etiology:


     Pediatric Radiology CasesHistory: *

    A one year old male child was brought with history of grossly delayed milestones and repeated bouts of seizure. History of premature delivery was given by parents.  

     Pediatric Radiology CasesPathomorphology or Pathophysiology of this disease : *

    The corpus callosum is a white matter structure located in the midline and composed of fibers that connect both cerebral hemispheres. The development of the corpus callosum begins during the fifth week of fetal life with the formation of the primitive lamina terminalis, which thickens to form the commissural plate. Glial cells coalesce to form a bridge like structure that serves as a guide for the callosal fibers crossing the longitudinal cerebral fissure to their targets on the contra lateral side of the brain. The mature corpus callosum is formed by the seventeenth week of gestation
    Complete agenesis of the corpus callosum may occur after inflammatory or vascular lesions before its complete development. Later insults result in partial agenesis of a previously normal corpus callosum; therefore, generally only the posterior portion is affected.
    Agenesis of corpus callosum (ACC) may be an isolated finding; however, it is frequently associated with other malformations and genetic syndromes including chromosomal aberrations and inborn errors of metabolism. Associated central nervous system abnormalities include Chiari malformations, anomalies of neuronal migration including lissencephaly, schizencephaly, pachygyria and polymicrogyria, encephalocele, Dandy-Walker malformations, holoprosencephaly, and olivopontocerebellar degeneration. Extra cranial malformations include abnormalities of the face and of the cardiovascular, genitourinary, gastrointestinal, respiratory, and musculoskeletal systems.
    Here, in this case it is associated with bilateral fronto-parietal gross encephalomalacea mainly involving the white matter, possibly suggesting hypoxic ischemic encephalopathy.  

     Pediatric Radiology CasesRadiological findings: *

    MRI 1 <- view MRI 1

    MRI 1: Axial T1WI showing dilated and separated ventricles with bilateral fronto-parietal encephalomalacic changes.

    MRI 2 <- view MRI 2

    MRI 2: Coronal T1WI showing absent corpus callosum with dilated ventricles and bilateral fronto-parietal encephalomalacea.

    MRI 3 <- view MRI 3

    MRI 3: Coronal T1WI showing colpocephaly.

    MRI 4 <- view MRI 4

    MRI 4: Sagittal T1WI showing complete absence of corpus callosum with encephalomalacic changes involving fronto-parietal white matter.

    MRI 5 <- view MRI 5

    MRI 5: Axial T2WI showing dilated ventricles with bilateral encephalomalacic changes.

    MRI 6 <- view MRI 6

    MRI 6: Axial T2WI showing absence corpus callosum more clearly.

    MRI 7 <- view MRI 7

    MRI 7: Coronal FLAIR image showing similar findings to coronal T1WI.


     Pediatric Radiology CasesDiagnosis confirmation:

    Expert's opinion  

     Pediatric Radiology CasesWhich DD would be also possible with the radiological findings: *

    Developmental anomaly , Infective lesion etc.  

     Pediatric Radiology CasesCourse / Prognosis / Frequency / Other : *

    Prognosis is dependent upon the cause of the malformation. In approximately 90% of the cases of isolated ACC, development is normal. ACC can even be an occasional finding in the investigation of children with mental retardation or microcephaly. There is no treatment for this condition

     Pediatric Radiology CasesComments of the author about the case: *

    In this case the parents were very poor to carry out any investigation as a result this was the first scan, in fact any investigation done after birth.The milestones were so much delayed that even the head lifting was not proper till one year. We did this MR scan on academic interest in our hospital and found this condition. Only palliative treatments were given. No definite improvement till date.  

     Pediatric Radiology CasesFirst description / History:


     Pediatric Radiology CasesLiterature:

    1. Medline: Medline
    Parrish ML, Roessmann U, Levinshon MW
    Agenesis of the corpus callosum: a study of the frequency of associated malformations
    Ann Neurol 1979;6:349-354

    2. Medline: Medline
    Jeret JS, Serur D, Wisniewski K, et al.
    Clinicopathological findings associated with agenesis of the corpus callosum
    Brain Dev 1987;9:255-60

    3. Medline: Medline
    Barkovitch AJ, Norman D
    Anomalies of the corpus callosum: correlation with further anomalies of the brain
    AJR AM J Roentgenol 1988;151:171-179

     Pediatric Radiology CasesKeywords: *

    Corpus callosum, Agenesis, Encephalomalacea, Colpocephaly, child, childhood, pediatric radiology  

     Pediatric Radiology Cases Cite this article:

    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.

     Pediatric Radiology Cases Read similar articles: with corresponding keywords
    in the same field: Head-Brain and brain nerves
    or in the region: Head
    or in the tissue/organ: Brain and brain nerves
    or with the etiology: circulatory
     Pediatric Radiology CasesImages to this case: There are MRI-images available for this case. [ MRI ] View all modalities [ All ]   

    Thanks to Martina Paetzel, M.D. for translating this case!

    Agenesis Of The Corpus Callosum
    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.


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    Agenesis Of The Corpus Callosum
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    Agenesis Of The Corpus Callosum  
    Agenesis Of The Corpus Callosum
    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.

    Agenesis Of The Corpus Callosum
    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.


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    Agenesis Of The Corpus Callosum
    Sanjeeb Kumar, GS Ahmed. Agenesis Of The Corpus Callosum. PedRad [serial online] vol 9, no. 4.


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