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    Go to the top of the page   ID: 20020126181655 Original case in english  More links about this topic on Pubmed (PubMed Reader)
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    Thalassemia intermedia
    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655


     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] View all modalities [ All ]   
     Pediatric Radiology CasesAuthor/s:

    M. Paetzel (Cleveland/USA)  

     
     Pediatric Radiology CasesEmail Address:

    Viewable for logged on visitors (Log on)  

     
     Pediatric Radiology CasesAge:

    9 Years  

     
     Pediatric Radiology CasesGender:

    Female  

     
     Pediatric Radiology CasesRegion-Organ:

    Head-Bones  

     
     Pediatric Radiology CasesMost likely etiology:

    congenital  

     
     Pediatric Radiology CasesHistory:

    9 year old girl, paleness, hepatosplenomegaly  

     
     Pediatric Radiology CasesPathomorphology or Pathophysiology of this disease :

    Autosomal hereditary hemoglobin defect with a resulting hypocromatic, microcytic anemia. Through hemolysis is an iron overload common. Extensive medullary and extramedullary bleeding.  

     
     Pediatric Radiology CasesRadiological findings:


    X-Ray 1 <- view X-Ray 1

    X-Ray 1: Lateral View



    X-Ray 2 <- view X-Ray 2

    X-Ray 2: Cranium (extensive): Macrocephaly with widend diploe, thinned tabula externa and subperiostal spiculae. Holes in the tablua externa re possible.




    X-Ray 3 <- view X-Ray 3

    X-Ray 3: Hand: Trabelces are affected in the metacarpals. Widening of the bone marrow and thinning of the cortical zone through the hypertophied blood-producing marrow..

    Further typical changes of the increased erythropoeisis is seen in the ribs, facial skeleton and in the vertebral bodies are possible not shown.

    In the MRI (T2): Signal reduction in bone marrow, in the liver and in the spleen (iron deposition).


     

     
     Pediatric Radiology CasesDiagnosis confirmation:

    Genetics  

     
     Pediatric Radiology CasesWhich DD would be also possible with the radiological findings:

    Other hemolytic anemias (spherocytosis, enzyme defects)  

     
     Pediatric Radiology CasesCourse / Prognosis / Frequency / Other :

    N/A  

     
     Pediatric Radiology CasesComments of the author about the case:

    N/A  

     
     Pediatric Radiology CasesFirst description / History:

    N/A  

     
     Pediatric Radiology CasesLiterature:

    N/A  

     
     Pediatric Radiology CasesKeywords:

    Paleness, hepatosplenomegaly, autosomal, hemoglobin defect, microcytic, anemia, Thalassemia intermedia, child, childhood, pediatric radiology  

     
     Pediatric Radiology Cases Cite this article:

    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655  

     
     Pediatric Radiology Cases Read similar articles: with corresponding keywords
    in the same field: Head-Bones
    or in the region: Head
    or in the tissue/organ: Bones
    or with the etiology: congenital
     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] View all modalities [ All ]   
     
    Thalassemia intermedia
    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655


     

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    Thalassemia intermedia
    Other cases by these authors:

    Search M. Paetzel in Medline M. Paetzel (10)   

    Thalassemia intermedia  
     
    Thalassemia intermedia
    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655


     
     
    Thalassemia intermedia
    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655


     

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    Thalassemia intermedia
    M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
    URL: www.PedRad.info/?search=20020126181655


     




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